Kat(ching) metabolism by the tail: Insight into the links between lysine acetyltransferases and metabolism
Post-translational modifications of histones elicit structural and functional changes within chromatin that regulate various epigenetic processes. Epigenetic mechanisms rely on enzymes whose activities are driven by co-enzymes and metabolites from intermediary metabolism. Lysine acetyltransferases (KATs) catalyze the transfer of acetyl groups from acetyl-CoA to epsilon amine groups. Utilization of this critical metabolite suggests these enzymes are modulated by the metabolic status of the cell. This review highlights studies linking KATs to metabolism. We cover newly identified acyl-modifications (propionylation and butyrylation), discuss the control of KAT activity by cellular acetyl-CoA levels, and provide insights into how acetylation regulates metabolic proteins. Lastly, we conclude with a discussion of the current approaches for identifying novel KATs and their metabolic substrates.
Link to Published Version
Albaugh, B. N., Arnold, K. M., & Denu, J. M. (2011). Kat(ching) metabolism by the tail: Insight into the links between lysine acetyltransferases and metabolism. ChemBioChem, 12(2), 290–298. doi:10.1002/cbic.201000438