doi:10.1016/S0960-894X(03)00683-8">
 

Title

Structure activity studies of a novel cytotoxic benzodiazepine

Document Type

Article

Publication Date

2003

Department/School

Chemistry

Abstract

Analogues of Bz-423, a pro-apoptotic 1,4-benzodiazepine with potent activity in animal models of systemic lupus erythematosus and rheumatoid arthritis, have been designed, synthesized, and evaluated in cell-culture assays. The results of these experiments have defined the structural elements of this new cytotoxic agent required for activity.

Link to Published Version

doi:10.1016/S0960-894X(03)00683-8