doi:10.1021/ol702941f">
 

Title

Synthesis of tert-Alkyl amino hydroxy carboxylic esters via an intermolecular ene-type reaction of oxazolones and enol ethers

Document Type

Article

Publication Date

2008

Department/School

Chemistry

Abstract

tert-Alkyl amino hydroxy carboxylic acids are abundantly present within the structure of many biologically active natural products. We describe herein the synthesis of these substrates using an oxazolone-mediated ene-type reaction with enol ethers followed by NaBH4 reduction of the intermediate oxazolone.

Link to Published Version

doi:10.1021/ol702941f