Title
Synthesis of tert-Alkyl amino hydroxy carboxylic esters via an intermolecular ene-type reaction of oxazolones and enol ethers
Document Type
Article
Publication Date
2008
Department/School
Chemistry
Abstract
tert-Alkyl amino hydroxy carboxylic acids are abundantly present within the structure of many biologically active natural products. We describe herein the synthesis of these substrates using an oxazolone-mediated ene-type reaction with enol ethers followed by NaBH4 reduction of the intermediate oxazolone.
Link to Published Version
Recommended Citation
Mosey, R. A., Fisk, J. S., Friebe, T. L., & Tepe, J. J. (2008). Synthesis of tert-Alkyl amino hydroxy carboxylic esters via an intermolecular ene-type reaction of oxazolones and enol ethers. Organic Letters, 10(5), 825–828. doi:10.1021/ol702941f