Date Approved
2009
Degree Type
Open Access Thesis
Degree Name
Master of Science (MS)
Department or School
Chemistry
Committee Member
Andrei Kornilov, PhD
Committee Member
Harriet Lindsay, PhD
Committee Member
Cory Emal, PhD
Abstract
Histone deacetylase inhibitors (HDIs) have found a wide variety of medicinal uses and are most noted for their specific apoptotic action towards cancer cells. Several hydroxamate HDIs have since been moved on to phase 1 and 2 clinical drug trials, with one having already been approved for treatment of advanced cutaneous T-cell lymphoma. Trichostatin A is one of the most potent known naturally-occurring inhibitors of histone deacetylase. Unfortunately for researchers, the syntheses that have been reported are both long and difficult, which leads to a low overall yield and therefore to a prohibitively expensive product, limiting its medicinal potential. This work builds on several previously published syntheses and shows a more efficient synthesis of Trichostatin A, which will make it more available for use in a variety of treatments.
Recommended Citation
Colombo, Joseph, "An improved synthesis of the HDAC inhibitor trichostatin A" (2009). Master's Theses and Doctoral Dissertations. 237.
https://commons.emich.edu/theses/237