Open Access Thesis
Master of Science (MS)
Dr. Deborah Heyl-Clegg, PhD, Chair
Amylin (Islet Amyloid Polypeptide, IAPP) is a 37 amino acid polypeptide, co-secreted with insulin from pancreatic beta cells, that plays a role in the damage of cell membranes by forming amyloid fibrils in Type 2 diabetes. Insulin has been found to inhibit hIAPP (Human Islet Amyloid Polypeptide) aggregation. The HLVEALYLVC amino acid region of insulin contacts hIAPP near the N-terminus. Truncated and modified analogs of insulin containing the binding region (VEALYLV, VEALFLV and EALYLV) were synthesized and purified, and their actions were studied on model lipid membranes in the presence of hIAPP 1-19 and hIAPP 1-37.
Peddi, Durgaprasad, "Insulin Based Inhibitors of Human Islet Amyloid Polypeptide (hIAPP) and Their Effect on hIAPP- Mediated Membrane Damage in Type 2 Diabetes Mellitus" (2009). Master's Theses and Doctoral Dissertations. 261.