Open Access Senior Honors Thesis
Department or School
Damage to insulin-producing beta cells of the pancreas in individuals with Type II Diabetes Mellitus is a traditional effect of the disease, which is often aggravated by age. A potential explanation for beta cell damage is disruption of the cellular lipid membrane from amylin accumulation. This presentation details an examination of possible age-related effects to membrane lipids, specifically differing levels of head group loss, through treatment of membrane models with amylin and dye leakage assays.
Joesten, William, "Lipid membrane disruption by amylin in type II diabetes mellitus: Effect of head group loss" (2012). Senior Honors Theses and Projects. 285.