Date Approved


Degree Type

Open Access Senior Honors Thesis

Department or School


First Advisor

Deborah Heyl-Clegg

Second Advisor

Heather Holmes


Damage to insulin-producing beta cells of the pancreas in individuals with Type II Diabetes Mellitus is a traditional effect of the disease, which is often aggravated by age. A potential explanation for beta cell damage is disruption of the cellular lipid membrane from amylin accumulation. This presentation details an examination of possible age-related effects to membrane lipids, specifically differing levels of head group loss, through treatment of membrane models with amylin and dye leakage assays.