Date Approved


Degree Type

Open Access Senior Honors Thesis

Department or School


First Advisor

Hannah Seidel

Second Advisor

Aaron Liepman

Third Advisor

Marianne Laporte


Tumors are characterized by over-proliferation of cells. However, not all tumors behave the same or have the same effects on surrounding non-tumorous tissues. Using the model organism C. elegans, we established tumor rupture trends in tumorous animals of three different genotypes. The characteristics studied include the effect of a germline tumor on the distribution of intermediate filament proteins in the endotube of the intestine, rate of tumor rupture between the hermaphrodites of each genotype, and tumor nuclear morphology of males and hermaphrodites of two genotypes. We conclude that tumors in C. elegans behave differently among the genotypes studied and the characteristics observed are dependent on sex, age, and genotype.

Included in

Biology Commons