Date Approved

2010

Degree Type

Open Access Thesis

Degree Name

Master of Science (MS)

Department or School

Health Promotion and Human Performance

Committee Member

Stephen J. McGregor, Ph.D., Chair

Committee Member

Lynne M. Shetron-Rama, Ph.D

Committee Member

Christopher Herman, Ph.D.

Abstract

The purpose of this study was to determine whether acute maximal sprint exercise would elicit an inflammatory response in trained and untrained runners marked by increased systemic immune proteins and byproducts of oxidation, as well as to determine a time course for the presence of these markers. In procedures approved by the Eastern Michigan University College of Health and Human Services Human Subjects Review Board, subjects participated in a total of five study visits consisting of both exercise and blood draws. Blood analysis seems to indicate that there was a secondary tissue injury, which was responsible for the greatest changes in the measured parameters, although a larger population must be examined to confirm these results. It was also noted that increased cytokine concentrations preceded an increase in oxidative byproducts, indicating the existence of a cytokine dependant cascade, in addition to that created by the initial mechanical insult.

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