Combining the platinum(II) drug candidate kiteplatin with 1,10-phenanthroline analogues

Authors

Benjamin J. Pages, Western Sydney University
Jennette Sakoff, Calvary Mater Newcastle
Jayne Gilbert, Calvary Mater Newcastle
Yingjie Zhang, Australian Nuclear Science and Technology Organisation
Sharon M. Kelly, University of Glasgow
James D. Hoeschele, Eastern Michigan University
Janice R. Aldrich-Wright, Western Sydney University

Document Type

Article

Publication Date

2018

Department/School

Chemistry

Publication Title

Dalton Transactions

Abstract

Platinum complexes of the type [Pt(PL)(AL)]2+ where PL is a derivative of 1,10-phenanthroline and AL is cis-1,4-diaminocyclohexane (1,4-dach), have been synthesised and characterised by ultraviolet spectroscopy, elemental microanalysis, nuclear magnetic resonance and X-ray crystallography. The calf-thymus DNA binding affinity of these complexes was determined by isothermal titration calorimetry, revealing higher DNA affinity than their 1S,2S-diaminocyclohexane analogues. In vitro cytotoxicity was assessed in eleven human cell lines, revealing unexpectedly low activity for the 1,4-dach complexes.

Link to Published Version

10.1039/c7dt04108j

Recommended Citation

Pages, B. J., Sakoff, J., Gilbert, J., Zhang, Y., Kelly, S. M., Hoeschele, J. D., & Aldrich-Wright, J. R. (2018). Combining the platinum(II) drug candidate kiteplatin with 1,10-phenanthroline analogues. Dalton Transactions, 47(7), 2156–2163. https://doi.org/10.1039/C7DT04108J