Pinpointing miRNA and genes enrichment over trait-relevant tissue network in Genome-Wide Association Studies
Document Type
Article
Publication Date
2020
Department/School
Biology
Publication Title
BMC Medical Genomics
Abstract
Understanding gene regulation is important but difficult. Elucidating tissue-specific gene regulation mechanism is even more challenging and requires gene co-expression network assembled from protein–protein interaction, transcription factor and gene binding, and post-transcriptional regulation (e.g., miRNA targeting) information. The miRNA binding affinity could therefore be changed by SNP(s) located at the 3′ untranslated regions (3′UTR) of the target messenger RNA (mRNA) which miRNA(s) interacts with. Genome-wide association study (GWAS) has reported significant numbers of loci hosting SNPs associated with many traits. The goal of this study is to pinpoint GWAS functional variants located in 3′UTRs and elucidate if the genes harboring these variants along with their targeting miRNAs are associated with genetic traits relevant to certain tissues.
Link to Published Version
Recommended Citation
Li, B., Dong, J., Yu, J., Fan, Y., Shang, L., Zhou, X., & Bai, Y. (2020). Pinpointing miRNA and genes enrichment over trait-relevant tissue network in Genome-Wide Association Studies. BMC Medical Genomics, 13(Suppl 11). https://doi.org/10.1186/s12920-020-00830-w