Title
Structure activity studies of a novel cytotoxic benzodiazepine
Document Type
Article
Publication Date
2003
Department/School
Chemistry
Abstract
Analogues of Bz-423, a pro-apoptotic 1,4-benzodiazepine with potent activity in animal models of systemic lupus erythematosus and rheumatoid arthritis, have been designed, synthesized, and evaluated in cell-culture assays. The results of these experiments have defined the structural elements of this new cytotoxic agent required for activity.
Link to Published Version
Recommended Citation
Boitano, A., Emal, C. D., Leonetti, F., Blatt, N. B., Dineen, T. A., Ellman, J. A., … Glick, G. D. (2003). Structure activity studies of a novel cytotoxic benzodiazepine. Bioorganic & Medicinal Chemistry Letters, 13(19), 3327–3330. doi:10.1016/S0960-894X(03)00683-8
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