Structure activity studies of a novel cytotoxic benzodiazepine
Analogues of Bz-423, a pro-apoptotic 1,4-benzodiazepine with potent activity in animal models of systemic lupus erythematosus and rheumatoid arthritis, have been designed, synthesized, and evaluated in cell-culture assays. The results of these experiments have defined the structural elements of this new cytotoxic agent required for activity.
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Boitano, A., Emal, C. D., Leonetti, F., Blatt, N. B., Dineen, T. A., Ellman, J. A., … Glick, G. D. (2003). Structure activity studies of a novel cytotoxic benzodiazepine. Bioorganic & Medicinal Chemistry Letters, 13(19), 3327–3330. doi:10.1016/S0960-894X(03)00683-8