Title
Microwave-induced synthesis of a cis–trans mixture of 2-butyl-5-phenyl-1,3-dioxolan-4-ones and their stereochemical determination using noesy 2-d nmr spectroscopy
Document Type
Article
Publication Date
2003
Department/School
Chemistry
Abstract
We report a new organic laboratory experiment designed for the undergraduate/advanced undergraduate student. In this experiment, students first model the two possible diastereomeric (cis–trans) dioxolanone products, predict the major isomer, and then go into the laboratory and rapidly synthesize the diastereomeric mixture using a domestic microwave oven as a heat source. Finally, the stereochemistry of the major isomer is confirmed using NOESY 2-D NMR spectroscopy.
Link to Published Version
Recommended Citation
Friebe, T. L. (2003). Microwave-induced synthesis of a cis–trans mixture of 2-butyl-5-phenyl-1,3-dioxolan-4-ones and their stereochemical determination using noesy 2-d nmr spectroscopy. The Chemical Educator, 8(2), 33–36.