Title
Ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit—Potential anti-metastatic drugs
Document Type
Article
Publication Date
2010
Department/School
Chemistry
Abstract
A series of ethacrynic acid analogues, lacking the alpha,beta-unsaturated carbonyl unit, was synthesized and subsequently evaluated for their ability to inhibit the migration of human breast cancer cells, MCF-7/AZ. Several of the analogues were already active in the low micromolar range, whereas ethacrynic acid itself shows no potential to inhibit the migration of these cancer cells. Preliminary studies show that the presence of one or more methoxy groups at the phenyl ring of ethacrynic acid is important in order for the ethacrynic acid analogues to demonstrate an inhibitory effect on the migration.
Link to Published Version
Recommended Citation
Janser, I., Janser, R. F. ., Meka, R. K., Bryant, Z. E., Adogla, E. A., Vogel, E. K., … Steelant, W. F. . (2010). Ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit—Potential anti-metastatic drugs. Bioorganic & Medicinal Chemistry Letters, 20(6), 1848–1850. doi:10.1016/j.bmcl.2010.01.144