Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism

Authors/Creators

Daniel A. Lawrence, University of Michigan - Ann Arbor
Cory Emal, Eastern Michigan University
Jacqueline Cale
Enming Joe Su, University of Michigan - Ann Arbor
Mark Warnock, University of Michigan - Ann Arbor
Shih-Hon Li, University of Michigan - Ann Arbor
Jeanne Ann Cupp

Document Type

Patent

Date of Patent

12-27-2016

Abstract

The invention relates to plasminogen activator-I (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

Original Assignee(s)

The Regents of the University of Michigan ; Eastern Michigan University

Comments

C. Emal is a faculty member in EMU's Department of Chemistry.

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Recommended Citation

Lawrence, D. A., Emal, C., Cale,J., Su, E. J., Warnock, M., Li, S.-H., Cupp, J. A. (2015). Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism (U.S. Patent No. 9,527,878). U.S. Patent and Trademark Office.

Patent Number

US 9,527,878