Date Approved


Degree Type

Open Access Thesis

Degree Name

Master of Science (MS)

Department or School

Health Sciences

Committee Member

Michael Switzer, Ph.D.

Committee Member

Jean Rowan, MD, MS


Hydroxychloroquine is a highly effective and commonly used disease-modifying anti-rheumatic drug (DMRD) for the treatment of various autoimmune diseases. Recently this medication received lot of attention in the medical world as a potential treatment for COVID-19. The goal of this research is to perform a systematic review of literature to focus on the efficacy of hydroxychloroquine in COVID-19 patients and any evidence of adverse reactions. The database used to conduct this research was PubMed, using four keywords and phrases: effects, side effects, adverse events, and serious adverse events of hydroxychloroquine in COVID-19 patients. Out of the 15 articles selected for the final review, 12 articles indicated no clinical improvement and 10 articles did not indicate any evidence of adverse reactions. The conclusion of the research is that hydroxychloroquine indicates lack of efficacy as treatment in patients with COVID-19, and there is not enough conclusive evidence for adverse reactions.