"Patient-centric barriers to clinical trial participation in developing" by Kirandeep Kaur

Date Approved

2025

Degree Type

Open Access Thesis

Degree Name

Master of Science (MS)

Department or School

Health Sciences

Committee Member

Michael Switzer, Ph.D.

Committee Member

Shannon Murray, MHS

Abstract

The underrepresentation of developing countries in clinical trials limits the applicability of research findings to a significant portion of the global population. This study addresses this gap by conducting a retrospective analysis of published literature to identify patient-centric barriers to clinical trial participation in developing countries. A comprehensive search of PubMed, Web of Science, and Cochrane Library databases yielded four relevant studies, which were subjected to thematic analysis. The study identified 12 key emerging themes, with safety and efficacy concerns and trust issues being the most prevalent. The thematic analysis partially supported the hypothesis: While trust issues were found in all studies and lack of awareness in 50%, cultural and religious factors did not emerge as a distinct theme. Addressing these barriers is crucial to increasing clinical trial participation in developing countries, promoting more equitable and generalizable medical advancements.

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